Tomohide Tatsumi Selected Research

MHC class I-related chain A

6/2010	Expression of CD133 confers malignant potential by regulating metalloproteinases in human hepatocellular carcinoma.
10/2009	Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma.
8/2008	Serum levels of soluble major histocompatibility complex (MHC) class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma.
12/2005	Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas.
11/2003	Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection.
2/2003	Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection.

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Tomohide Tatsumi Research Topics

Disease

50	Neoplasms (Cancer) 12/2022 - 09/2002
49	Hepatocellular Carcinoma (Hepatoma) 12/2022 - 04/2003
25	Infections 01/2022 - 02/2003
24	Chronic Hepatitis C 01/2022 - 02/2003
15	Liver Cirrhosis (Hepatic Cirrhosis) 10/2022 - 10/2004
13	Fibrosis (Cirrhosis) 10/2022 - 03/2011
7	Virus Diseases (Viral Diseases) 01/2022 - 02/2003
7	Inflammation (Inflammations) 11/2021 - 02/2010
6	Liver Diseases (Liver Disease) 01/2022 - 08/2008
6	Liver Neoplasms (Liver Cancer) 09/2016 - 01/2007
5	Hepatitis 01/2021 - 01/2007
5	Hepatitis C 10/2020 - 03/2011
5	Colonic Neoplasms (Colon Cancer) 09/2013 - 01/2003
5	Chronic Hepatitis (Chronic Active Hepatitis) 05/2012 - 10/2008
4	Carcinogenesis 01/2022 - 05/2012
4	Non-alcoholic Fatty Liver Disease 11/2021 - 01/2016
4	Renal Cell Carcinoma (Grawitz Tumor) 01/2021 - 09/2002
4	Chronic Hepatitis B 01/2016 - 02/2006
4	Melanoma (Melanoma, Malignant) 05/2010 - 09/2002
3	Disease Progression 02/2022 - 12/2008
3	Fatty Liver 01/2021 - 07/2017
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020 - 12/2013
3	Anemia 08/2019 - 02/2010
3	Hepatitis B 10/2018 - 01/2009
3	Neoplasm Metastasis (Metastasis) 09/2016 - 03/2007
2	Breast Neoplasms (Breast Cancer) 01/2022 - 04/2013
2	Adenocarcinoma 01/2020 - 07/2017
2	Massive Hepatic Necrosis 10/2018 - 01/2007
2	Pancreatitis 01/2018 - 12/2012

Drug/Important Bio-Agent (IBA)

18	Antiviral Agents (Antivirals)IBA 10/2022 - 01/2007
17	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2003
17	InterferonsIBA 10/2020 - 09/2010
17	Ribavirin (Virazole)FDA LinkGeneric 08/2019 - 01/2011
14	Peptides (Polypeptides)IBA 02/2011 - 09/2002
10	micaIBA 10/2019 - 02/2003
9	VaccinesIBA 10/2018 - 12/2002
8	Fetal Proteins (Fetoprotein)IBA 12/2022 - 07/2014
8	Sorafenib (BAY 43-9006)FDA Link 04/2021 - 04/2010
8	AntigensIBA 05/2010 - 09/2002
7	RNA (Ribonucleic Acid)IBA 05/2022 - 03/2012
7	CytokinesIBA 01/2022 - 10/2002
7	SofosbuvirIBA 01/2021 - 11/2015
6	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 02/2006
6	Small Interfering RNA (siRNA)IBA 07/2017 - 10/2010
6	MHC class I-related chain AIBA 06/2010 - 02/2003
6	EpitopesIBA 12/2008 - 09/2002
5	Biomarkers (Surrogate Marker)IBA 02/2022 - 01/2016
5	Lamivudine (Epivir)FDA Link 05/2012 - 06/2008
5	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 10/2007 - 08/2003
4	lenvatinibIBA 07/2022 - 11/2019
4	Glycoproteins (Glycoprotein)IBA 11/2021 - 03/2011
4	Aspartate Aminotransferases (Aspartate Transaminase)IBA 11/2021 - 02/2014
4	BilirubinIBA 09/2020 - 10/2009
4	Transcription Factors (Transcription Factor)IBA 01/2020 - 12/2012
4	NucleotidesIBA 11/2015 - 01/2007
4	alpha-galactosylceramideIBA 06/2009 - 08/2003
4	LigandsIBA 12/2008 - 11/2003
3	Bevacizumab (Avastin)FDA Link 07/2022 - 02/2022
3	atezolizumabIBA 07/2022 - 02/2022
3	Phosphotransferases (Kinase)IBA 01/2022 - 10/2010
3	Hepatitis B Surface Antigens (HBsAg)FDA Link 01/2022 - 04/2013
3	Hepatitis B e AntigensIBA 01/2022 - 05/2012
3	Growth Differentiation Factor 15IBA 01/2022 - 01/2021
3	ledipasvirIBA 01/2021 - 11/2015
3	Acetylcysteine (Siran)FDA LinkGeneric 01/2021 - 08/2015
3	sofosbuvir drug combination ledipasvirIBA 08/2018 - 12/2017
3	SimeprevirIBA 07/2017 - 03/2016
3	MicroRNAs (MicroRNA)IBA 05/2017 - 05/2010
3	entecavir FDA Link 07/2015 - 06/2008
3	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2008 - 01/2003
3	EphA2 ReceptorIBA 12/2008 - 08/2005
3	Transforming Growth Factor beta (TGF-beta)IBA 11/2008 - 10/2004
2	Interleukin-6 (Interleukin 6)IBA 02/2022 - 11/2007
2	alpha-Fetoproteins (alpha-Fetoprotein)IBA 01/2022 - 07/2015
2	LipidsIBA 01/2022 - 12/2016
2	Hyaluronic Acid (Hyaluronan)IBA 01/2022 - 11/2021
2	pgRNAIBA 01/2022 - 01/2020
2	Warfarin (Coumadin)FDA LinkGeneric 01/2022 - 11/2019
2	EnzymesIBA 05/2021 - 08/2003
2	Nonesterified Fatty Acids (NEFA)IBA 01/2021 - 07/2017
2	velpatasvirIBA 01/2021 - 01/2019
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2020 - 11/2007
2	Lipase (Acid Lipase)FDA Link 01/2018 - 12/2012
2	Connective Tissue Growth FactorIBA 01/2018 - 08/2011
2	telaprevirIBA 07/2017 - 03/2015
2	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2016 - 08/2015
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2016 - 12/2012
2	Branched-Chain Amino AcidsIBA 09/2016 - 07/2013
2	Messenger RNA (mRNA)IBA 09/2016 - 05/2010
2	Inosine Triphosphate (ITP)IBA 03/2016 - 03/2014
2	CholesterolIBA 01/2016 - 11/2014
2	NucleosidesIBA 07/2015 - 01/2009
2	Galactosylceramides (Galactocerebrosides)IBA 09/2013 - 02/2011
2	Alanine Transaminase (SGPT)IBA 04/2013 - 11/2011
2	Cytostatic AgentsIBA 08/2012 - 10/2010

Therapy/Procedure

35	Therapeutics 03/2022 - 12/2002
6	Immunotherapy 05/2022 - 12/2002
4	Drug Therapy (Chemotherapy) 07/2022 - 10/2009
2	Radiofrequency Ablation 12/2022 - 07/2015
2	Radiotherapy 01/2022 - 12/2013